Symbol Name ID |
Atm
ataxia telangiectasia mutated MGI:107202 |
Darker colors indicate more annotations |
Human Phenotypes | Decreased circulating IgA level |
Decreased circulating IgG level |
Decreased circulating IgG2 level |
Defective B cell differentiation |
Abnormal B cell count |
Decreased proportion of CD4-positive helper T cells |
T lymphocytopenia |
Lymphopenia |
Leukemia |
Acute lymphoblastic leukemia |
Lymphoma |
Hodgkin lymphoma |
Non-Hodgkin lymphoma |
Hepatosplenomegaly |
Disease(s) Associated with ATM | ||||||||||||||
ataxia telangiectasia | ||||||||||||||
pancreatic cancer |
Mouse Phenotypes | impaired macrophage phagocytosis |
thymus cortex hypoplasia |
small thymus |
decreased thymocyte number |
enlarged spleen |
abnormal class switch recombination |
decreased immature B cell number |
abnormal T cell differentiation |
abnormal CD4-positive T cell differentiation |
abnormal CD8-positive, alpha-beta T cell differentiation |
increased double-negative T cell number |
decreased double-positive T cell number |
increased double-positive T cell number |
increased B-1 B cell number |
increased B-1a cell number |
decreased B cell number |
decreased pre-B cell number |
increased B cell number |
increased central memory CD4-positive, alpha-beta T cell number |
increased effector memory CD4-positive, alpha-beta T cell number |
decreased CD4-positive, alpha-beta T cell number |
increased central memory CD8 positive, alpha-beta T cell number |
increased CD8-positive, alpha-beta memory T cell number |
decreased CD8-positive, naive alpha-beta T cell number |
decreased CD8-positive, alpha-beta T cell number |
decreased T cell number |
decreased activated T cell number |
decreased single-positive T cell number |
increased single-positive T cell number |
decreased lymphocyte cell number |
increased macrophage cell number |
abnormal lymphocyte morphology |
small spleen |
decreased splenocyte number |
decreased IgG2a level |
decreased IgG2b level |
decreased IgG3 level |
decreased IgG level |
increased IgM level |
abnormal T cell physiology |
abnormal microglial cell physiology |
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Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||||
Atmm1Btlr/Atmm1Btlr | ||||||||||||||||||||||||||||||||||||||||||
Atmm2Btlr/Atmm2Btlr | ||||||||||||||||||||||||||||||||||||||||||
Atmm3Btlr/Atmm3Btlr | ||||||||||||||||||||||||||||||||||||||||||
AtmM4Btlr/AtmM4Btlr | ||||||||||||||||||||||||||||||||||||||||||
Atmm5Btlr/Atmm5Btlr | ||||||||||||||||||||||||||||||||||||||||||
Atmm6Btlr/Atmm6Btlr | ||||||||||||||||||||||||||||||||||||||||||
Atmtm1.1Mmpl/Atmtm1.1Mmpl | ||||||||||||||||||||||||||||||||||||||||||
Atmtm1Awb/Atmtm1Awb | ||||||||||||||||||||||||||||||||||||||||||
Atmtm1Bal/Atmtm1Bal | ||||||||||||||||||||||||||||||||||||||||||
Atmtm1Fwa/Atmtm1Fwa | ||||||||||||||||||||||||||||||||||||||||||
Atmtm1Led/Atmtm1Led | ||||||||||||||||||||||||||||||||||||||||||
Atmtm1Mfl/Atmtm1Mfl | ||||||||||||||||||||||||||||||||||||||||||
Atmtm2.1Mfgc/Atmtm2.1Mfgc | ||||||||||||||||||||||||||||||||||||||||||
Atmtm2.1Fwa/Atmtm2.1Fwa Tg(VAV1-cre)1Graf/0 (conditional) |
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Atmtm1Shzh/Atmtm2.1Fwa Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+ (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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